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GPR120 Agonist III-Calbiochem

品牌
Sigma-Aldrich
货号
371822
规格纯度
The GPR120 Agonist III controls the biological activity of GPR120. This small molecule/inhibitor is primarily used for Activators/Inducers applications.
参考价格
2185.87 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
GPR120 Agonist III-Calbiochem
3-(4-((4-Fluoro-4'-methyl-(1,1'-biphenyl)-2-yl)methoxy)-phenyl)propanoic acid
产品介绍:

产品说明

一般描述

A membrane-permeant biphenyl-methoxy-phenylpropanoate compound that acts as an active-site targeting, selective, potent agonist of G-protein coupled receptor 120/GPR120 (EC50 of β-arrestin 2 recruitment = 17 nM and 44 nM for mGPR120 and hGPR120, respectively; EC50 of Ca++ mobilization = 96 nM for hGPR120). Exhibits much reduced potency toward free fatty acid receptor 1/FFA1/GPR40 (EC50 of β-arrestin 2 recruitment = 64.6 µM) and no activity toward short chain FFA receptors FFA2/GPR43 and FFA3/GPR41.

包装

25 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
G-protein coupled receptor 120
Reversible: yes

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Shimpukade, B., et al. 2012. J. Med. Chem.55, 4511.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C23H21FO3
分子量364.41
MDL编号MFCD22421654

产品性质

质量水平100
测定≥97% (HPLC)
形式powder
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 white
溶解性DMSO: 100 mg/mL
运输ambient
储存温度2-8℃
SMILES stringO=C(O)CCC1=CC=C(OCC2=CC(F)=CC=C2C3=CC=C(C)C=C3)C=C1

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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