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位置:首页 > 品牌 > Sigma-Aldrich > Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1-CAS 313553-47-8-Calbiochem

Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1-CAS 313553-47-8-Calbiochem

品牌
Sigma-Aldrich
CAS
313553-47-8
货号
373270
规格纯度
The Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1, also referenced under CAS 313553-47-8, controls the biological activity of Hec1/Nek2 Mitotic Pathway.
参考价格
8484.48 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
313553-47-8
Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1-CAS 313553-47-8-Calbiochem
Inhibitor of Nek2/Hec1-1, N-(4-(2,4-Dimethylphenyl)-thiazol-2-yl)-benzamide, INH1
N-(4-(2,4-Dimethylphenyl)-thiazol-2-yl)-benzamide, INH1, Inhibitor of Nek2/Hec1-1
产品介绍:

产品说明

一般描述

A cell-permeable thiazolyl benzamide compound that directly binds Hec1 and disrupts Hec1/Nek2 complex formation, resulting in defective Hec1 kinetochores localization and cellular Nek2 destabilization/downregulation. Shown to induce a transient mitotic arrest in HeLa cultures and inhibit the proliferation of 10 breast cancer cell lines (GI50 of 10-21 µM) as well as the cervical HeLa and colon HCT116 cancer lines, while exhibiting reduced potency against the noncancerous MCF10A line (GI50 = 41 µM). Reported to suppress the MDA-MB-468-derived tumor growth (by ~53% and ~75% 3 wks after a 7-wk treatment period with 50 mg/kg and 100 mg/kg INH1, repectively, i.p.) in a murine breast cancer model in vivo.

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Wu, G., et al. 2008. Cancer Res.68, 8393.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C18H16N2OS
分子量308.40

产品性质

质量水平100
测定≥97% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 white
溶解性DMSO: 50 mg/mL
ethanol: 50 mg/mL
运输ambient
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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