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位置:首页 > 品牌 > Sigma-Aldrich > HIF Prolyl Hydroxylase Inhibitor-CAS 385786-48-1-Calbiochem

HIF Prolyl Hydroxylase Inhibitor-CAS 385786-48-1-Calbiochem

品牌
Sigma-Aldrich
CAS
385786-48-1
货号
400084
包装型号
规格纯度
参考价格
1954.93 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
385786-48-1
HIF Prolyl Hydroxylase Inhibitor-CAS 385786-48-1-Calbiochem
产品介绍:

产品说明

一般描述

A cell-permeable, hydroxyquinoline HIF Prolyl Hydroxylase (PHD) inhibitor that displays an IC50 = 2 µM in a cell-based assay using a reporter produced by fusing HIF-1α oxygen degradable domain (ODD) to luciferase. This compound (5 µM) is shown to significantly stabilize HIF-1α in vitro and upregulate known HIF target genes, Epo and VEGF, in SH-SY5Y human neuroblastoma cell lines. It also exerts a neuroprotective effect (IC50 = 0.25 µM in an oxidative stress model using cortical neurons.

包装

10 mg in Glass bottle

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Smirnova, N.A., et al. 2010. Chem. Biol.4, 380.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C21H16ClN3O
分子量361.82

产品性质

质量水平100
测定≥95% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
颜色 tan
溶解性DMSO: 50 mg/mL
运输ambient
储存温度−20℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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