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InSolution Akt Inhibitor X-CAS 925681-41-0-Calbiochem

品牌
Sigma-Aldrich
CAS
925681-41-0
货号
124039
规格纯度
The InSolution Akt Inhibitor X, also referenced under CAS 925681-41-0, controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
参考价格
2566.78 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
925681-41-0
InSolution Akt Inhibitor X-CAS 925681-41-0-Calbiochem
10-(4'-(N,N-Diethylamino)butyl)-2-chlorophenoxazine, HCl, 4-(2-Chloro-10H-phenoxazin-10-yl)-N,N-diethylbutan-1-amine, HCl
4-(2-Chloro-10H-phenoxazin-10-yl)-N,N-diethylbutan-1-amine, HCl, 10-(4'-(N,N-Diethylamino)butyl)-2-chlorophenoxazine, HCl
产品介绍:

产品说明

一般描述

A cell-permeable, reversible, and selective inhibitor of the phosphorylation of Akt and its in vitro kinase activity (complete inhibition <5 M) with minimal effect on PI 3-K, PDK1, or SGK1. Shown to suppress growth of Rh (rhabdomyosarcoma) cell lines (IC50 = 2-5 M), inhibit IGF-I-stimulated nuclear translocation of Akt, and prevent phosphorylation of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein. Unlike Akti1/2, the mode of inhibition is not PH domain-dependent. Also shown to induce neuronal autophagy in an Akt- and mTOR-independent manner and enhances the clearance of misfolded protein. The solid form of this compound is also available.

包装

2 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
Akt
Reversible: yes

警告

Toxicity: Standard Handling (A)

外形

A 20 mM (2 mg/262 µL) solution of Akt Inhibitor X (Cat. No. 124020) in H₂O.

重悬

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.

其他说明

Tsvetkov, A.S., et al. 2010. Proc. Natl. Acad. Sci. USA107, 16982.
Thimmaiah, K.N., et al. 2005. J. Biol. Chem.280, 31924.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C20H25ClN2O · xHCl
分子量344.88 (free base basis)

产品性质

质量水平100
测定≥97% (HPLC)
形式liquid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
avoid repeated freeze/thaw cycles
protect from light
运输dry ice
储存温度−70℃
SMILES stringClC(C=C1)=CC2=C1OC3=C(N2CCCCN(CC)CC)C=CC=C3

安全信息

储存分类代码12 - Non Combustible Liquids
WGKnwg
闪点(F)Not applicable
闪点(C)Not applicable

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