产品说明
一般描述
A cell-permeable tetrahydroisoquinolinylidene compound that modulates Wnt/β-catenin signaling by targeting the PR72/130 subunit of PP2A and thereby blocking PP2A/Nkd complex formation, resulting in diminished β-catenin/p300 interaction and a concomitant increase in β-catenin/CBP usage. Co-adminitration of IQ-1 (4 µg/ml) and Wnt3a (100 ng/ml), but neither reagent alone, has been shown to be sufficient in maintaining long-term (>48 days) murine ESCs (Embryonic Stem Cells) pluripotency in the absence of serum.
包装
10 mg in Plastic ampoule
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
其他说明
Miyabayashi, T., et al. 2007. Proc. Natl. Acad. Sci. USA104, 5668.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C21H22N4O2 |
| 分子量 | 362.42 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze protect from light |
| 颜色 | orange |
| 溶解性 | DMSO: 50 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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