您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 品牌 > Sigma-Aldrich > IRE1 Inhibitor I, STF-083010-Calbiochem

IRE1 Inhibitor I, STF-083010-Calbiochem

品牌
Sigma-Aldrich
货号
412510
规格纯度
The IRE1 Inhibitor I, STF-083010 controls the biological activity of IRE1. This small molecule/inhibitor is primarily used for Biochemicals applications.
参考价格
1903.37 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
IRE1 Inhibitor I, STF-083010-Calbiochem
N-[(2-Hydroxynaphthalen-1-yl)methylidene]thiophene-2-sulfonamide, N-[(2-Hydroxy-1-naphthyl)methylene]-2-thiophenesulfonamide, ER-to-Nucleus Signaling 1 Inhibitor I, ERN1 Inhibitor I, Inositol-Reguiring Protein 1 Inhibitor I, STF083010
ER-to-Nucleus Signaling 1 Inhibitor I, ERN1 Inhibitor I, Inositol-Reguiring Protein 1 Inhibitor I, STF083010, N-[(2-Hydroxynaphthalen-1-yl)methylidene]thiophene-2-sulfonamide, N-[(2-Hydroxy-1-naphthyl)methylene]-2-thiophenesulfonamide
产品介绍:

产品说明

一般描述

A cell-permeable salicylidene compound that is shown to directly target Ireα1 and disrupt Ire1-XBP1 (X-box binding protein) unfolded protein response (UPR) pathway in RPMI8226 multiple myeloma (MM) cells. Selectively inhibits ER stress-initiated endonuclease activity of Ire1 and blocks XPB1 mRNA splicing in MM cells at 60 µM and XBP1 activity in transgenic XBP1-luc mice (bortezomib 1mg/kg and 60 mg/kg of STF-083010, i.p.). Displays preferential cytotoxicity towards CD138+ cells over B, T and NK cells and antitumor properties.

包装

10 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Regulatory Review (Z)

重悬

Unstable in solution; reconstitute just prior to use.

其他说明

Lerner, A.G., et al. 2012 Cell Metabolism16, 250.
Papandreou, I., et al. 2010. Blood117, )1311.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C15H11NO3S2
分子量317.38
MDL编号MFCD02332975
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 yellow
溶解性DMSO: 100 mg/mL, clear, yellow
运输ambient
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品