Ketoconazole-CAS 65277-42-1-Calbiochem

产品名称：

65277-42-1
Ketoconazole-CAS 65277-42-1-Calbiochem
cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine, R-41400, CYP17A1 Inhibitor I

产品介绍：

产品说明

一般描述

An inhibitor of cytochrome P-450 in steroid biosynthesis. An anti-fungal agent that displays potent anti-metastatic, anti-neoplastic, and anti-psoriatic activities. Also acts as an inhibitor of 5-lipoxygenase (5-LO; IC₅₀ = 26 µM) and thromboxane synthase activities.
An inhibitor of cytochrome P-450 in steroid biosynthesis. An antifungal agent that displays potent anti-metastatic, anti-neoplastic, and anti-psoriatic activities. Also acts as an inhibitor of 5-lipoxygenase (5-LO; IC₅₀ = 26 µM) and thromboxane synthase activities.

包装

50 mg in Glass bottle

生化/生理作用

Primary Target
5-LO

警告

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

其他说明

van Wauwe, J.P., and Janssen, P.A.J. 1989. J. Med. Chem. 32, 2231.
Beetens, J.R., et al. 1986. Biochem. Pharmacol. 35, 883.
Lambert, A., et al. 1986. Biochem. Pharmacol. 35, 3999.
Tucker, W.F.G., and MacNeil, S. 1986. Br. Med. J. 293, 882.
Lelcuk, S., et al. 1984. J. Trauma 24, 393.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₆H₂₈Cl₂N₄O₄
分子量	531.43
MDL编号	MFCD00058579

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
效能	26 μM IC₅₀
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze
颜色	off-white
运输	ambient
储存温度	2-8℃
InChI	1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m1/s1
InChI key	XMAYWYJOQHXEEK-ZEQKJWHPSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H301 - H360F - H373 - H410
预防措施声明	P201 - P202 - P260 - P264 - P273 - P301 + P310
危险分类	Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 1B - STOT RE 2
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable