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位置:首页 > 品牌 > Sigma-Aldrich > (S)-2- {4-[(2,4-二氨基胍-6-基)甲氨基]苯甲酰氨基}戊二酸

Methotrexate Related Compound B

4-氨基-PGA

品牌
USP
CAS
54-62-6
货号
1414025
规格纯度
United States Pharmacopeia (USP) Reference Standard
参考价格
12328.4 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
54-62-6
Methotrexate Related Compound B
4-Aminopteroyl-L-glutamic acid
4-Aminofolic Acid
(S)-2-{4-[(2,4-Diaminopteridin-6-yl)methylamino]benzamido}pentanedioic acid
4-Amino-PGA
Aminopterin
氨基蝶呤
N-[4-[[(2,4-二氨基-6-蝶啶)甲基]氨基]苯甲酰]-L-谷氨酸
(S)-2- {4-[(2,4-二氨基胍-6-基)甲氨基]苯甲酰氨基}戊二酸
4-氨基-PGA
4-氨基叶酸
产品介绍:

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

叶酸拮抗剂。氨基蝶呤是由叶酸转运蛋白运输至细胞内的。在细胞内,它被叶酰聚谷氨酸合酶转化为一种高分子量的聚谷氨酸盐代谢物,该产物又与二氢叶酸还原酶结合并抑制其活性。氨基蝶呤-聚谷氨酸盐经 γ-谷氨酰基水解酶作用发生细胞内降解。

联系

比甲氨喋呤更有效,但毒性也更强。

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式C19H20N8O5
分子量440.41
Beilstein69045
PubChem化学物质编号329750411
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
ε (extinction coefficient)24,500 at 282 nm in 0.1 M NaOH at 1 M
25,700 at 261 nm in 0.1 M NaOH at 1 M
8,100 at 373 nm in 0.1 M NaOH at 1 M
application(s)pharmaceutical (small molecule)
格式neat
SMILES stringNc1nc(N)c2nc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2n1
InChI1S/C19H20N8O5/c20-15-14-16(27-19(21)26-15)23-8-11(24-14)7-22-10-3-1-9(2-4-10)17(30)25-12(18(31)32)5-6-13(28)29/h1-4,8,12,22H,5-7H2,(H,25,30)(H,28,29)(H,31,32)(H4,20,21,23,26,27)/t12-/m0/s1
InChI keyTVZGACDUOSZQKY-LBPRGKRZSA-N

安全信息

象形图GHS06GHS08
警示用语:Danger
危险声明H300 - H360
预防措施声明P201 - P280 - P301 + P330 + P331 + P310 - P308 + P313
危险分类Acute Tox. 2 Oral - Repr. 1B
储存分类代码6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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