MIF Antagonist V, p425-CAS 259444-Calbiochem

产品名称：

2610-05-1
MIF Antagonist V, p425-CAS 259444-Calbiochem
Sodium 6,6'-(1 E,1' E)-(3,3'-dimethoxybiphenyl-4,4'-diyl) bis(diazene-2,1-diyl) bis(4-amino-5-hydroxynaphthalene-1,3-disulfonate)
Sodium 6,6'-(1E,1'E)-(3,3'-dimethoxybiphenyl-4,4'-diyl)bis(diazene-2,1-diyl)bis(4-amino-5-hydroxynaphthalene-1,3-disulfonate)

产品介绍：

产品说明

一般描述

A symmetrical bis-(amino, hydroxynaphthalenedisulfonate) compound that antagonizes macrophage migration inhibitory factor against receptor binding (IC₅₀ = 810 nM against hMIF and CD74 interaction) and is more potent than ISO-1 (Cat. No. 475837) in suppressing both MIF-induced IL-6 and IL-8 production in human foreskin fibroblasts (IC₅₀ = 0.6 - 0.7 µM vs >5 µM) and MIF-induced MMP-3 production in human synovial fibroblasts (IC₅₀ = 0.1 µM vs >10 µM). Shown to exhibit little cytotoxicity in human foreskin fibroblast cultures even at concentrations as high as 100 µM. Unlike MIF Antagonists I-IV, p425 targets an area at the interface of two MIF trimers, distal to the active site.
A symmetrical bis-(amino, hydroxynaphthalenedisulfonate) compound that antagonizes macrophage migration inhibitory factor against receptor binding (IC₅₀ = 810 nM against hMIF and CD74 interaction) and is more potent than ISO-1 (Cat. No. 475837) in suppressing MIF-induced cytokines and MMP-3 productions in human fibroblasts cultures (IC₅₀ = ≤0.7 µM vs >5 µM). Unlike MIF Antagonists I-IV, p425 targets an area at the interface of two MIF trimers, distal to the active site.

包装

2 g in Glass bottle
Packaged under inert gas

生化/生理作用

Primary Target
MIF
Reversible: yes

警告

Toxicity: Harmful (C)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Bai, F., et al. 2012. J. Biol. Chem.287, 30653.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₃₄H₂₄N₆Na₄O₁₆S₄
分子量	992.80
MDL编号	MFCD00004020

产品性质

质量水平	100
测定	≥95% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze desiccated (hygroscopic) protect from light
颜色	blue
溶解性	water: 25 mg/mL
运输	ambient
储存温度	2-8℃
SMILES string	OC1=C(C=CC(C(S(=O)(O[Na])=O)=C2)=C1C(N)=C2S(=O)(O[Na])=O)/N=N/C3=CC=C(C=C3OC)C4=CC(OC)=C(/N=N/C5=C(O)C6=C(C(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C6N)C=C5)C=C4
InChI	1S/C34H28N6O16S4.4Na/c1-55-23-11-15(3-7-19(23)37-39-21-9-5-17-25(57(43,44)45)13-27(59(49,50)51)31(35)29(17)33(21)41)16-4-8-20(24(12-16)56-2)38-40-22-10-6-18-26(58(46,47)48)14-28(60(52,53)54)32(36)30(18)34(22)42;;;;/h3-14,37-38H,35-36H2,1-2H3,(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54);;;;/q;4*+1/p-4/b39-21-,40-22+;;;;
InChI key	UPKAWFACSJWKND-ZXFFUEEESA-J

安全信息

象形图
警示用语：	Danger
危险声明	H350
预防措施声明	P201 - P202 - P280 - P308 + P313 - P405 - P501
危险分类	Carc. 1B
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable