产品说明
一般描述
A cell-permeable trans-stilbene Resveratrol (Cat. No. 554325) analog that exhibits much enhanced anti-inflammatory potency, but no anti-oxidant activity. Suppresses LPS-induced COX-2 mRNA expression in BV-2 cells (~46% inhibition at 150 nM) and Shown to be ~130-fold more potent than Resveratrol in inhibiting TNF-α-stimulated NF-κB reporter activity in 293T cells (IC50 = 150 nM).
包装
10 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Target IC50: 150 nM inhibiting TNF-α-stimulated NF-κB reporter activity in 293T cells.
Primary Target
NF-κB Activation
Product does not compete with ATP.
Reversible: no
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Heynekamp, J.J., et al. 2006. J. Med. Chem.49, 7182.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C15H13FO |
| 分子量 | 228.26 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | crystalline solid |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze protect from light |
| 溶解性 | DMSO: 20 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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