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NF023-Calbiochem

品牌
Sigma-Aldrich
货号
480415
规格纯度
A suramin analog that acts as a selective and direct G-protein antagonist for α-subunits of the Go/Gi group (EC50 ~ 300 nM).
参考价格
4137.78 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
NF023-Calbiochem
8,8'-[Carbonylbis(imino-3,1-phenylene)]bis-(1,3,5-naphthalenetrisulfonic Acid), 6Na, P2X Antagonist I, Purinergic Receptor P2X Antagonist I
产品介绍:

产品说明

一般描述

A suramin analog that acts as a selective and direct G-protein antagonist for α-subunits of the Go/Gi group (EC50 ~ 300 nM). Suppresses GTPγS binding to recombinant G-protein α-subunits. Acts by inhibiting the formation of the agonist-specific ternary complex (agonist/receptor/G-protein). NF023 does not interfere with the interaction between α-subunits and βγ-dimer but competes with the effector binding site. Also a P2X receptor antagonist (IC50 = 240 nM for P2X1; 8.5 µM for P2X3 receptor in rat muscle). Causes a concentration dependent inhibition of excitatory junction potentials (IC50 = 4.8 pM).
A suramin analog that acts as a selective G-protein antagonist for α-subunits of the Go/Gi group (EC50 ~300 nM). Suppresses GTPγS binding to recombinant G-protein α-subunits. Acts by inhibiting the formation of the agonist-specific ternary complex (agonist/receptor/G-protein). NF023 does not interfere with the interaction between α-subunits βγ-dimer but competes with the effector binding site. Also a P2X receptor antagonist (IC50=0.24 µM for P2X1; 8.5 µM for P2X3 receptor in rat muscle).

包装

10 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Primary Target
α-subunits of the Go/Gi group of G-protein
Product does not compete with ATP.
Reversible: no
Target IC50: 240 nM for P2X1; 8.5 µM for P2X3 receptor in rat muscle; 4.8 pM in the inhibition of excitatory junction potentials; EC50 ~ 300 nM as G-protein antagonist for α-subunits of the Go/Gi group
Cell permeable: no

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.

其他说明

Snedden, P., et al. 2000. Br. J. Pharmacol.129, 1089.
Soto, F., et al. 1999. Neuropharmacology38, 141.
Beindle, W., et al. 1996. Mol. Pharmacol.50, 415.
Freissmuth, M., et al. 1996. Mol. Pharmacol.49, 602.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C35H20N4O21S6 · 6Na
分子量1162.88

产品性质

质量水平100
测定≥95% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
desiccated (hygroscopic)
颜色 white to off-white
溶解性water: soluble
运输ambient
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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