Nrf2 Activator III, TAT-14 Peptide-Calbiochem

品牌

Sigma-Aldrich

货号

492042

包装型号

10 MG, The Nrf2 Activator III, TAT-14 Peptide modulates the biological activity of Nrf2. This small molecule/inhibitor is primarily used for Biochemicals applications.

规格纯度

The Nrf2 Activator III, TAT-14 Peptide modulates the biological activity of Nrf2. This small molecule/inhibitor is primarily used for Biochemicals applications.

参考价格

3932.26 元 *本价格含增值税费

促销

数量

产品名称：

Nrf2 Activator III, TAT-14 Peptide-Calbiochem
H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg~Leu-Gln-Leu-Asp-Glu-Glu-Thr-Gly-Glu-Phe-Leu-Pro-Ile-Gln-OH

产品介绍：

产品说明

一般描述

A 14-mer peptide (LQLDEETGEFLPIQ) conjugated to cell-penetrating trans-activating transcriptional activator (TAT) sequence (YGRKKRRQRRRLQ) that targets the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) binding site on Kelch-like ECH-associated protein 1 (Keap1). Competitively disrupts Nrf2-Keap1 interaction and stabilizes cytosolic Nrf2, and promotes its nuclear translocation and binding to the antioxidant response element (ARE). Exhibits anti-inflammatory properties and increases heme-oxygenase-1 gene expression (~75 µM). Also shown to suppress LPS-induced TNF-α secretion in THP-1 monocytes (~ 37.5 µM).

包装

10 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

序列

H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg~Leu-Gln-Leu-Asp-Glu-Glu-Thr-Gly-Glu-Phe-Leu-Pro-Ile-Gln-OH

外形

Supplied as a trifluoroacetate salt.

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Steel, R., et al. 2012. ACS Med Chem Lett.3, 407.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₃₇H₂₃₀N₄₈O₃₉
分子量	3173.59

产品性质

质量水平	100
测定	≥95% (HPLC)
形式	powder
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze desiccated (hygroscopic) protect from light
颜色	white
溶解性	DMSO: 100 mg/mL
运输	ambient
储存温度	−20℃