Nrf2 Activator III, TAT-14 Peptide-Calbiochem

产品说明

一般描述

A 14-mer peptide (LQLDEETGEFLPIQ) conjugated to cell-penetrating trans-activating transcriptional activator (TAT) sequence (YGRKKRRQRRRLQ) that targets the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) binding site on Kelch-like ECH-associated protein 1 (Keap1). Competitively disrupts Nrf2-Keap1 interaction and stabilizes cytosolic Nrf2, and promotes its nuclear translocation and binding to the antioxidant response element (ARE). Exhibits anti-inflammatory properties and increases heme-oxygenase-1 gene expression (~75 µM). Also shown to suppress LPS-induced TNF-α secretion in THP-1 monocytes (~ 37.5 µM).

包装

10 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

序列

H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg~Leu-Gln-Leu-Asp-Glu-Glu-Thr-Gly-Glu-Phe-Leu-Pro-Ile-Gln-OH

外形

Supplied as a trifluoroacetate salt.

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Steel, R., et al. 2012. ACS Med Chem Lett.3, 407.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

产品性质