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Phalloidin–Atto 700

品牌
Sigma-Aldrich
货号
79286
规格纯度
suitable for fluorescence, ≥80.0% (HPCE)
参考价格
6543.9 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
Phalloidin–Atto 700
Atto 700–Phalloidin
产品介绍:

产品说明

一般描述

Atto 700 belongs to a new generation of fluorescent labels. The dye is designed for application in the area of life science, e.g. labeling of DNA, RNA or proteins. Characteristic features of the label are strong absorption, high fluorescence quantum yield, excellent thermal and photo-stability, very good water solubility and very little triplet formation. Atto 700 is a zwitterionic dye with a net electrical charge of zero. The fluorescence is efficiently quenched by electron donors like guanine, tryptophan, etc
Phalloidin is a fungal toxin isolated from the poisonous mushroom Amanita phalloides. Its toxicity is attributed to the ability to bind F actin in liver and muscle cells. As a result of binding phalloidin, actin filaments become strongly stabilized. Phalloidin has been found to bind only to polymeric and oligomeric forms of actin, and not to monomeric actin. The dissociation constant of the actin-phalloidin complex has been determined to be on the order of 3 x 10-8. Phalloidin differs from amanitin in rapidity of action; at high dose levels, death of mice or rats occurs within 1 or 2 hours. Fluorescent conjugates of phalloidin are used to label actin filaments for histological applications. Some structural features of phalloidin are required for the binding to actin. However, the side chain of amino acid 7 (g-d-dihydroxyleucine) is accessible for chemical modifications without appreciable loss of affinity for actin.

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包装

Bottomless glass bottle. Contents are inside inserted fused cone.

法律信息

This product is for Research use only. In case of intended commercialization, please contact the IP-holder (ATTO-TEC GmbH, Germany) for licensing.

基本信息

NACRESNA.32

产品性质

质量水平100
测定≥80.0% (HPCE)
形式powder
荧光λex 700 nm; λem 719 nm in 0.1 M phosphate pH 7.0
适用性suitable for fluorescence
储存温度−20℃

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3

Sigma-Aldrich

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