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Phalloidin–Atto 725

品牌
Sigma-Aldrich
货号
51865
规格纯度
suitable for fluorescence, ≥80% (HPCE)
参考价格
7430.15 *本价格含增值税费
促销
服务
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数量
-+
产品名称:
Phalloidin–Atto 725
Atto 725–Phalloidin
产品介绍:

产品说明

一般描述

Atto 725 belongs to a new generation of fluorescent labels for the near infrared spectral region. The dye is designed for application in the area of life science, e.g. labeling of DNA, RNA or proteins. Characteristic features of the dye are strong absorption and good fluorescence as well as excellent thermal and photo-stability. Atto 725 is a cationic dye. After coupling to a substrate the dye carries a net electrical charge of +1.
Atto 725 is a pH sensitive product. While practically stable up to pH 7.4 (PBS-buffer), it slowly degrades at higher pH. If exposed to higher pH for coupling purposes, we recommend reducing the pH immediately after completion of the reaction.
Phalloidin is a fungal toxin isolated from the poisonous mushroom Amanita phalloides. Its toxicity is attributed to the ability to bind F actin in liver and muscle cells. As a result of binding phalloidin, actin filaments become strongly stabilized. Phalloidin has been found to bind only to polymeric and oligomeric forms of actin, and not to monomeric actin. The dissociation constant of the actin-phalloidin complex has been determined to be on the order of 3 x 10-8. Phalloidin differs from amanitin in rapidity of action; at high dose levels, death of mice or rats occurs within 1 or 2 hours. Fluorescent conjugates of phalloidin are used to label actin filaments for histological applications. Some structural features of phalloidin are required for the binding to actin. However, the side chain of amino acid 7 (g-d-dihydroxyleucine) is accessible for chemical modifications without appreciable loss of affinity for actin.

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包装

Bottomless glass bottle. Contents are inside inserted fused cone.

法律信息

This product is for Research use only. In case of intended commercialization, please contact the IP-holder (ATTO-TEC GmbH, Germany) for licensing.

基本信息

NACRESNA.32

产品性质

质量水平100
测定≥80% (HPCE)
荧光λex 725 nm; λem 755 nm in 0.1 M phosphate pH 7.0
适用性suitable for fluorescence
储存温度−20℃

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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