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Pifithrin-μ-CAS 64984-31-2-Calbiochem

品牌
Sigma-Aldrich
CAS
64984-31-2
货号
506155
规格纯度
A cell-permeable sulfonamide that blocks p53 interaction with Bcl-xL and Bcl-2 proteins and selectively inhibits p53 translocation to mitochondria without affecting the transactivation function of p53.
参考价格
1903.37 *本价格含增值税费
促销
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数量
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产品名称:
64984-31-2
Pifithrin-μ-CAS 64984-31-2-Calbiochem
Phenylacetylenylsulfonamide, Hsp70 Inhibitor I
产品介绍:

产品说明

一般描述

A cell-permeable sulfonamide that blocks p53 interaction with Bcl-xL and Bcl-2 proteins and selectively inhibits p53 translocation to mitochondria without affecting the transactivation function of p53. Effectively protects against γ radiation-induced cell death in vitro and animal lethality in vivo. Because Pifithrin-μ targets only the mitochondrial branch of the p53 pathway without affecting the important transcriptional functions of p53, it is superior to Pifithrin-α (Cat. No. 506132) in in vivo studies. Shown to selectively interact with inducible HSP70 and disrupt its functions.

包装

10 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
p53 interaction with Bcl-xL and Bcl-2 proteins
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Leu, J., et al. 2009. Mol. Cell36, 15.
Strom, E., et al. 2006. Nat. Chem. Biol.2, 474.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C8H7NO2S
分子量181.21
MDL编号MFCD00181531

产品性质

质量水平100
测定≥95% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 off-white
溶解性DMSO: 50 mg/mL
运输ambient
储存温度2-8℃
InChI1S/C8H7NO2S/c9-12(10,11)7-6-8-4-2-1-3-5-8/h1-5H,(H2,9,10,11)
InChI keyZZUZYEMRHCMVTB-UHFFFAOYSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3

Sigma-Aldrich

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