Polo-like Kinase Inhibitor IV, SBE13-CAS 775294-82-1-Calbiochem

品牌

Sigma-Aldrich

CAS

775294-82-1

货号

528281

包装型号

10 MG, The Polo-like Kinase Inhibitor IV, SBE13, also referenced under CAS 775294-82-1, controls the biological activity of Polo-like Kinase. This small molecule/inhibitor is primarily used for Phosphorylati

规格纯度

The Polo-like Kinase Inhibitor IV, SBE13, also referenced under CAS 775294-82-1, controls the biological activity of Polo-like Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

参考价格

2165.23 元 *本价格含增值税费

促销

数量

产品名称：

775294-82-1
Polo-like Kinase Inhibitor IV, SBE13-CAS 775294-82-1-Calbiochem
N-(4-((6-Chloro-3-pyridinyl)methoxy)-3-methoxybenzyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amine

产品介绍：

产品说明

一般描述

A cell-permeable vanillin-derived pyridyl-ethanamine compound that acts as a highly potent type II Plk1 inhibitor (IC₅₀ of 200 pM) and targets the less conserved DFG motif that is only accessible when the kinase is in its inactive DFG-out conformation, resulting in an excellent selectivity over Plk2 (IC₅₀ >66 µM), Plk3 (IC₅₀ = 875 nM), and aurora A kinase (no detectable effect). Shown to inhibit the proliferation of HeLa cells with an EC₅₀ of 18 µM.

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Keppner, S., et al. 2009. ChemMedChem.4, 1806.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₄H₂₇ClN₂O₄
分子量	442.94

产品性质

质量水平	100
测定	≥94% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze protect from light
颜色	beige
溶解性	DMSO: 25 mg/mL
运输	ambient
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable