Pomalidomide-dipiperazine-NH<sub>2</sub> hydrochloride

产品名称：

Pomalidomide-dipiperazine-NH₂ hydrochloride
4-(4-(4-(2-Aminoethyl)piperazine-1-carbonyl)piperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride
Protein degrader building block for PROTAC research
Pomalidomide conjugate
Template for synthesis of targeted protein degrader
Crosslinker-E3 Ligase ligand conjugate

产品介绍：

产品说明

应用

Protein degrader building block Pomalidomide-dipiperazine-NH₂ hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a rigid linker, and a pendant amine for reactivity with an acid on the target warhead. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

其他说明

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

基本信息

经验(实验)分子式	C₂₄H₃₁N₇O₅ · xHCl
分子量	497.55 (free base basis)

产品性质

质量水平	100
测定	≥95%
形式	powder
储存温度	2-8℃
SMILES string	O=C(N(C1CCC(NC1=O)=O)C2=O)C3=C2C=CC=C3N4CCN(C(N5CCN(CCN)CC5)=O)CC4

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

Pomalidomide-dipiperazine-NH2 hydrochloride

Pomalidomide-dipiperazine-NH₂ hydrochloride