Pomalidomide-piperazine-piperidine-4-carboxamide hydrochloride

产品名称：

Pomalidomide-piperazine-piperidine-4-carboxamide hydrochloride
2-(2,6-Dioxopiperidin-3-yl)-4-(4-(piperidine-4-carbonyl)piperazin-1-yl)isoindoline-1,3-dione hydrochloride
Protein degrader building block
Crosslinker-E3 Ligase ligand conjugate

产品介绍：

产品说明

应用

Protein degrader building block Pomalidomide-piperazine-piperidine-4-carboxamide hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC^® (proteolysis-targeting chimeras) research. This conjugate contains a Cereblon (CRBN) recruiting ligand, a rigid linker, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate degrader libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

其他说明

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

基本信息

经验(实验)分子式	C₂₃H₂₇N₅O₅ · xHCl
分子量	453.49 (free base basis)

产品性质

质量水平	100
储存温度	2-8℃
SMILES string	O=C1C(N2C(C(C=CC=C3N4CCN(C(C5CCNCC5)=O)CC4)=C3C2=O)=O)CCC(N1)=O.Cl