PTP Inhibitor V, PHPS1-CAS 314291-83-3-Calbiochem

品牌

Sigma-Aldrich

CAS

314291-83-3

货号

540213

包装型号

10 MG, The PTP Inhibitor V, PHPS1, also referenced under CAS 314291-83-3, controls the biological activity of PTP. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation

规格纯度

The PTP Inhibitor V, PHPS1, also referenced under CAS 314291-83-3, controls the biological activity of PTP. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

参考价格

2340.22 元 *本价格含增值税费

促销

数量

产品名称：

314291-83-3
PTP Inhibitor V, PHPS1-CAS 314291-83-3-Calbiochem
PhenylHydrazonoPyrazolone Sulfonate 1, PTPNN1 Inhibitor, 4-(N'-(3-(4-Nitrophenyl)-5-oxo-1-phenyl-1,5-dihydro-pyrazol-(4Z)-ylidene)-hydrazino)-benzenesulfonic acid, EC-PTP/PCPTP1 Inhibitor I, MptpA Inhibitor, PTP-SL Inhibitor I, PTP1B Inhibitor V, SHP1 Inhibitor VI, SHP2 Inhibitor III
4-(N'-(3-(4-Nitrophenyl)-5-oxo-1-phenyl-1,5-dihydro-pyrazol-(4Z)-ylidene)-hydrazino)-benzenesulfonic acid, PhenylHydrazonoPyrazolone Sulfonate 1, PTPNN1 Inhibitor, EC-PTP/PCPTP1 Inhibitor I, MptpA Inhibitor, PTP-SL

产品介绍：

产品说明

一般描述

A cell-permeable phosphotyrosine mimetic that acts as a reversible, active-site targeting, substrate-competitive inhibitor of Shp-2 (IC₅₀ and K_i = 2.1 and 0.73 µM, respectively). PHPS1 inhibits ECPTP, PTP1B, Shp1, mycobacterium MptpA only at higher concentrations (IC₅₀ = 5.4, 19, 30, and 39 µM, respectively) and exhibits little activity against PTPH1, STEP, PTPN7, PTPRK, GLEPP1, or LAR2 even at concentrations as high as 50 µM. Shown to inhibit Shp-2-dependent cellular signaling and tumor cell colonies formation.

包装

10 mg in Plastic ampoule
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

其他说明

Hellmuth, K., et al. 2008. Proc. Natl. Acad. Sci. USA105, 7275.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₁H₁₅N₅O₆S
分子量	465.44

产品性质

质量水平	100
测定	≥95% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze desiccated (hygroscopic) protect from light
颜色	reddish
溶解性	DMSO: 10 mg/mL
运输	ambient
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable