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Riluzole-CAS 1744-22-5-Calbiochem

品牌
Sigma-Aldrich
CAS
1744-22-5
货号
557324
规格纯度
A cell-permeable benzothiazole compound that potently inhibits glutamate release and blocks Na+ channels.
参考价格
1445.69 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
1744-22-5
Riluzole-CAS 1744-22-5-Calbiochem
2-Amino-6-(trifluoromethoxy)benzothiazole, PK 26124
产品介绍:

产品说明

一般描述

A cell-permeable benzothiazole compound that potently inhibits glutamate release and blocks Na+ channels. Reported to function as a polyglutamine aggregation inhibitor and stimulate the synthesis of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and glial cell-derived neurotrophic factor (GDNF) in mouse astrocyte cultures. Offers neuroprotection, slows disease progression in amyotrophic lateral sclerosis (ALS) patients, and prolongs survival in animal models of Huntington′s disease (HD).
A cell-permeable benzothiazole compound that potently inhibits glutamate release and blocks Na+ channels. Shown to function as a polyglutamine aggregation inhibitor and stimulates the synthesis of NGF, BDNF, and GDNF in mouse astrocyte cultures. Reported to offer neuroprotection, slow down disease progression in ALS (amyotrophic lateral sclerosis) patients, and prolong the lifespan of animal models of HD (Huntington’s disease).

包装

50 mg in Alu drum
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
Inhibits glutamate release and blocks Na+ channels

警告

Toxicity: Toxic (F)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Heiser, V., et al. 2002. Proc. Natl. Acad. Sci. USA99, 16400.
Schiefer, J., et al. 2002. Mov. Disord.17, 748.
Mizuta, I., et al. 2001. Neurosci. Lett.310, 117.
Louvel, E., et al. 1997. Trends Pharmacol. Sci.18, 196.
Mizoule, J., et al. 1985. Neuropharmacology24, 767.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C8H5F3N2OS
分子量234.20
MDL编号MFCD00210213

产品性质

质量水平100
测定≥97% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 white to off-white
溶解性HCl: 0.1 N
DMSO: 40 mg/mL
痕量阳离子heavy metals: ≤20 ppm
运输ambient
储存温度2-8℃
InChI1S/C8H5F3N2OS/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5/h1-3H,(H2,12,13)
InChI keyFTALBRSUTCGOEG-UHFFFAOYSA-N

安全信息

象形图GHS06
警示用语:Danger
危险声明H300
预防措施声明P264 - P270 - P301 + P310 - P405 - P501
危险分类Acute Tox. 2 Oral
储存分类代码6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGKWGK 3

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