RNA Polymerase III Inhibitor-CAS 577784-91-9-Calbiochem

产品说明

一般描述

A cell-permeable indazolo-sulfonamide compound that displays broad-spectrum inhibitory activity against RNA Polymerase III (IC₅₀ = 27 and 32 µM for human and S. cerevisiae RNA Pol III, respectively). Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription. Also available as a 25 mM solution in DMSO (Cat. No. 557404).
A cell-permeable inhibitor of RNA polymerase III (RNA Pol III) (IC₅₀ = 27 µM for human RNA Pol III and 32 µM for Saccharomyces cerevisiae RNA Pol III). Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription.

包装

10 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Product does not compete with ATP.
Cell permeable: yes
Primary Target
activity against RNA Polymerase III
Reversible: no
Target IC₅₀: 27 and 32 µM for Human and S. cerevisiae RNA Pol III

警告

Toxicity: Carcinogenic / Teratogenic (D)

制备说明

Slight warming may be necessary to achieve complete solubilization.

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Wu, L., et al. 2003. Euk. Cell2, 256.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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