SBAP (Succinimidyl 3-(bromoacetamido)propionate)

产品名称：

产品介绍：

产品说明

一般描述

SBAP is a sulfhydryl-reactive and amine-reactive heterobifunctional crosslinker. The reagent′s NHS ester reacts with primary amines at pH 7-9 to form stable amide bonds, and the bromacetyl reacts with sulfhydryl groups at pH >7.5 to form stable thioether bonds This reagent is useful for preparing cyclic peptides and peptide conjugates because the spacer maintains peptide-like character in the crosslinked species.

特点和优势

Reactive groups: NHS ester and bromoacetyl
Reactive toward: amino and sulfhydryl groups
NHS ester reacts with primary amines at pH 7-9 to form a stable amide bond
Bromacetyl group reacts with sulfhydryl groups at pH > 7.5 to form stable thioether bonds
Non-cleavable
Water-insoluble (dissolve first in DMF or DMSO)
Spacer maintains peptide-like character in the crosslinked species
Resulting crosslink is susceptible to acid hydrolysis
Useful for preparing cyclic peptides and peptide conjugates

注意

This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.

基本信息

经验(实验)分子式	C₉H₁₁N₂O₅Br
分子量	307.10
MDL编号	MFCD01863457
PubChem化学物质编号	329768824
NACRES	NA.22

产品性质

质量水平	100
测定	≥90%
形式	powder
分子量	307.1
reaction suitability	reagent type: cross-linking reagent
储存条件	desiccated
溶解性	DMSO or DMF: soluble
运输	ambient
储存温度	2-8℃
SMILES string	O=C(CCC1=O)N1OC(CCNC(CBr)=O)=O
InChI	1S/C9H11BrN2O5/c10-5-6(13)11-4-3-9(16)17-12-7(14)1-2-8(12)15/h1-5H2,(H,11,13)
InChI key	WGMMKWFUXPMTRW-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H315 - H319 - H335
预防措施声明	P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
危险分类	Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable