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SILuTMLite HAVCR1 Hepatitis A virus cellular receptor 1 human

品牌
Sigma-Aldrich
货号
MSST0042
规格纯度
recombinant, expressed in HEK 293 cells, MS Protein Standard
参考价格
9134.92 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
SILuTMLite HAVCR1 Hepatitis A virus cellular receptor 1 human
T-cell immunoglobulin mucin receptor 1 (TIM-1)
T-cell immunoglobulin and mucin domain-containing protein 1 (TIMD-1)
Kidney injury molecule 1 (KIM-1)
产品介绍:

产品说明

一般描述

HAVCR1 is a trans-membrane glycoprotein that is highly expressed in kidney proximal tubular cells with kidney injury. The KIM-1 ectodomain is cleaved, released into urine, and canbe quantified as a sensitive and specific biomarker for Acute Kidney Injury (AKI) in rodents and humans. In a recent study it was demonstrated that HAVCR1 is released into the circulation where it reports kidney injury in mice, rats, and humans with AKI and chronic kidney disease (CKD). Urinary HAVCR1 and MCP-1 levels, either alone or in combination, were significantly higher than those in AKI negative patients. Importantly, the combination of HAVCR1 and MCP-1 outperformed either biomarker alone.

免疫原

SVKVGGEAGPSVTLPCHYSGAVTSMCWNRGSCSLFTCQNGIVWTNGTHVTYRKDTRYKLLGDLSRRDVSLTIENTAVSDSGVYCCRVEHRGWFNDMKITVSLEIVPPKVTTTPIVTTVPTVTTVRTSTTVPTTTTVPTTTVPTTMSIPTTTTVLTTMTVSTTTSVPTTTSIPTTTSVPVTTTVSTFVPPMPLPRQNHEPVATSPSSPQPAETHPTTLQGAIRREPTSSPLYSYTTDGNDTVTESSDGLWNNNQTQLFLEHSLLTANTTKGDYKDDDDKGHHHHHHHHGGQ

生化/生理作用

SILuLite HAVCR1 is a recombinant human protein expressed in human 293 cells. It is a protein consisting of 290 amino acids acids (the extracellular domain: Ser21-Gly290, and including C-terminal polyhistidine and FLAG® tags), with a calculated molecular mass of 31 kDa. SILu Lite HAVCR1 is an analytical standard designed to be used as starting material for preparation of calibrators and controls in LC-MS applications.

外形

Supplied as a lyophilized powder containing phosphate buffered saline.

法律信息

FLAG is a registered trademark of sigma-aldrich Co. LLC
SILu is a trademark of sigma-aldrich Co. LLC

基本信息

NACRESNA.12

产品性质

质量水平200
生物来源human
重组expressed in HEK 293 cells
标签8-His tagged
测定≥98% (SDS-PAGE)
形式lyophilized powder
效能≥98% Heavy amino acids incorporation efficiency by MS
分子量calculated mol wt 31 kDa
technique(s)mass spectrometry (MS): suitable
适用性suitable for mass spectrometry (internal calibrator)
UniProt登记号Q96D42
储存温度−20℃
Gene Informationhuman ... HAVCR1(26762)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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