产品说明
一般描述
SILu™ Prot B2M is a recombinant, stable isotope-labeled human B2M which incorporates [13C6, 15N4]-Arginine and [13C6, 15N2]-Lysine. Expressed in human 293 cells, it is designed to be used as an internal standard for bioanalysis of B2M in mass-spectrometry. SILu™ Prot B2M is a monomer of 119 amino acids (including C-terminal polyhistidine and flag tags), with a molecular weight of ~14 kDa.
Suggested Quantitative Analysis Parameters
(MRM settings provided for three suggested peptides)
生化/生理作用
B2M is the light chain of the major histocompatibility class (MHC) I molecule expressed on the cell surface of all nucleated cells. Increased urinary B2M excretion has been observed to be an early marker of tubular injury in a number of settings, including nephrotoxicant exposure, cardiac surgery, and renal transplantation, preceding rises in serum creatinine by as many as 4−5 days. B2M may also serve as an early biomarker for AKI (Acute Kidney Injury).
序列
IQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDMDYKDDDDKGHHHHHHHHGGQ
外形
Supplied as a lyophilized powder containing phosphate buffered saline.
法律信息
SILu is a trademark of sigma-aldrich Co. LLC
基本信息
| NACRES | NA.12 |
产品性质
| 质量水平 | 200 |
| 生物来源 | human |
| 重组 | expressed in HEK 293 cells |
| 测定 | ≥98% (SDS-PAGE) |
| 形式 | lyophilized powder |
| 效能 | ≥98% Heavy amino acids incorporation efficiency by MS |
| technique(s) | mass spectrometry (MS): suitable |
| 适用性 | suitable for mass spectrometry (standard) |
| UniProt登记号 | P61769 |
| 储存温度 | −20℃ |
| Gene Information | human ... B2M(567) |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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