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位置:首页 > 品牌 > Sigma-Aldrich > SILuTMProt HAVCR1 Hepatitis A virus cellular receptor 1 human

SILuTMProt HAVCR1 Hepatitis A virus cellular receptor 1 human

品牌
Sigma-Aldrich
货号
MSST0041
规格纯度
recombinant, expressed in HEK 293 cells, SIL MS Protein Standard, 13C and 15N-labeled
参考价格
9134.92 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
SILuTMProt HAVCR1 Hepatitis A virus cellular receptor 1 human
T-cell immunoglobulin mucin receptor 1 (TIM-1)
Kidney injury molecule 1 (KIM-1) human
T-cell immunoglobulin and mucin domain-containing protein 1 (TIMD-1)
mucin domain-containing protein 1 (TIMD-1)
产品介绍:

产品说明

一般描述

HAVCR1 is a trans-membrane glycoprotein that is highly expressed in kidney proximal tubular cells with kidney injury. The KIM-1 ectodomain is cleaved, released into urine, and canbe quantified as a sensitive and specific biomarker for Acute Kidney Injury (AKI) in rodents and humans. In a recent study it was demonstrated that HAVCR1 is released into the circulation where it reports kidney injury in mice, rats, and humans with AKI and chronic kidney disease (CKD). Urinary HAVCR1 and MCP-1 levels, either alone or in combination, were significantly higher than those in AKI negative patients. Importantly, the combination of HAVCR1 and MCP-1 outperformed either biomarker alone.

免疫原

SVKVGGEAGPSVTLPCHYSGAVTSMCWNRGSCSLFTCQNGIVWTNGTHVTYRKDTRYKLLGDLSRRDVSLTIENTAVSDSGVYCCRVEHRGWFNDMKITVSLEIVPPKVTTTPIVTTVPTVTTVRTSTTVPTTTTVPTTTVPTTMSIPTTTTVLTTMTVSTTTSVPTTTSIPTTTSVPVTTTVSTFVPPMPLPRQNHEPVATSPSSPQPAETHPTTLQGAIRREPTSSPLYSYTTDGNDTVTESSDGLWNNNQTQLFLEHSLLTANTTKGDYKDDDDKGHHHHHHHHGGQ

生化/生理作用

SILuProt HAVCR1 is a recombinant, stable isotope-labeled human HAVCR1 which incorporates [13C6, 15N4]-Arginine and [13C6, 15N2]-Lysine. Expressed in human 293 cells, it is designed to be used as an internal standard for bioanalysis of HAVCR1 in mass-spectrometry. SILu Prot HAVCR1 is a protein consisting of 290 amino acids (the extracellular domain: Ser21-Gly290, and including C-terminal polyhistidine and FLAG® tags), with a calculated molecular mass of 31 kDa.

外形

Supplied as a lyophilized powder containing phosphate buffered saline.

法律信息

This product is licensed under U.S. Patent No. 7,396,688 and foreign counterparts from E. I. du Pont de Nemours and Company. The purchase of this product conveys to the buyer the nontransferable right to use the purchased amount of the product for research and development only, including services for a third party for consideration. The buyer cannot sell or otherwise transfer this product, its components or materials made using this product or its components to a third party. Information about licenses for excluded uses is available from: E. I. du Pont de Nemours and Company; Attn: Associate Director, Commercial Development; DuPont Experimental Station E268; 200 Powdermill Rd.; Wilmington, DE 19803; 1-877-881-9787 (voice), 1-302-695-1437 (fax), licensing@dupont.com.
FLAG is a registered trademark of sigma-aldrich Co. LLC
SILu is a trademark of sigma-aldrich Co. LLC

基本信息

NACRESNA.12

产品性质

质量水平200
生物来源human
重组expressed in HEK 293 cells
标签8-His tagged
测定≥98% (SDS-PAGE)
形式lyophilized powder
效能≥98% Heavy amino acids incorporation efficiency by MS
分子量calculated mol wt 31 kDa
technique(s)mass spectrometry (MS): suitable
适用性suitable for mass spectrometry (standard)
UniProt登记号Q96D42
储存温度−20℃
Gene Informationhuman ... HAVCR1(26762)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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