您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 品牌 > Sigma-Aldrich > STAT3 Inhibitor IX, Cpd188-CAS 823828-18-8-Calbiochem

STAT3 Inhibitor IX, Cpd188-CAS 823828-18-8-Calbiochem

品牌
Sigma-Aldrich
CAS
823828-18-8
货号
573125
规格纯度
The STAT3 Inhibitor IX, Cpd188, also referenced under CAS 823828-18-8, controls the biological activity of STAT3.
参考价格
1954.93 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
823828-18-8
STAT3 Inhibitor IX, Cpd188-CAS 823828-18-8-Calbiochem
4-((3-(Carboxymethylsulfanyl)-4-hydroxy-1-naphthyl)sulfamoyl)benzoic acid
产品介绍:

产品说明

一般描述

A cell-permeable naphthol compound that inhibits IL-6-stimulated STAT3 Tyr705 phosphorylation and nuclear translocation in HepG2 cells (IC50 = 73 and 39 µM, respectively) by targeting STAT3 SH2 domain peptide-binding pocket (IC50 = 20 µM against EGFR-derived pY-peptide binding), while exhibiting little effect against IFN-γ-stimulated HepG2 cellular STAT1 phosphorylation even at concentrations as high as 300 µM. Shown to preferentially induce apoptosis in cultures expressing constitutively active STAT3 (EC50 = 0.73, 3.96, and 7.01 µM in MDA-MB-468, MDA-MB-231, and MDA-MB-435 cultures, respectively), while being less effective against cells without constitutively active STAT3 (EC50 = 15.5 and 17.19 µM in MDA-MB-453 and MCF7 cultures, respectively).

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Xu, X., et al. 2009. PLoS One4, e4783.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C19H15NO7S2
分子量433.45

产品性质

质量水平100
测定≥95% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 beige
溶解性DMSO: 100 mg/mL
运输ambient
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品