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STAT3 Inhibitor V, Stattic-CAS 19983-44-9-Calbiochem

STAT3 抑制剂 V,Stattic-CAS 19983-44-9-Calbiochem

品牌
Sigma-Aldrich
CAS
19983-44-9
货号
573099
规格纯度
STAT3 Inhibitor V, Stattic, CAS 19983-44-9, is a cell-permeable inhibitor of STAT3 cellular function that targets the STAT3-SH2 domain and prevents its association with upstream Kinases.
参考价格
3543.57 *本价格含增值税费
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数量
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产品名称:
19983-44-9
STAT3 Inhibitor V, Stattic-CAS 19983-44-9-Calbiochem
6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound
STAT3 抑制剂 V,Stattic-CAS 19983-44-9-Calbiochem
产品介绍:

产品说明

一般描述

A cell-permeable vinyl-sulfone compound that acts as an inhibitor of STAT3 cellular function by targeting the STAT3-SH2 domain and preventing its association with upstream kinases. The effect of Stattic towards STAT family members is temperature-dependent and appears to be highly STAT3-selective at 37°C. Shown to inhibit cellular phosphorylation of STAT3 at Tyr705 with little effect towards STAT1 phosphorylation at Tyr701 (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells).

包装

25 mg in Plastic Bag(s)
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
STAT3

警告

Toxicity: Irritant (B)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Note: The use of freshly opened DMSO strongly recommended; the thiol impurities present in DMSO will modify the molecule. Highly recommended to reconstitute just before each use.

其他说明

Schust, J., et al. 2006. Chem. Biol.13, 1235.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C8H5NO4S
分子量211.19
MDL编号MFCD00173799

产品性质

质量水平100
测定≥95% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色pale yellow
溶解性DMSO: 10 mg/mL
ethanol: 5 mg/mL
运输ambient
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3

Sigma-Aldrich

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