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位置:首页 > 品牌 > Sigma-Aldrich > Tankyrase1/2 Inhibitor IV, JW55-CAS 664993-53-7-Calbiochem

Tankyrase1/2 Inhibitor IV, JW55-CAS 664993-53-7-Calbiochem

品牌
Sigma-Aldrich
CAS
664993-53-7
货号
575547
规格纯度
The Tankyrase1/2 Inhibitor IV, JW55 controls the biological activity of Tankyrase1/2. This small molecule/inhibitor is primarily used for Biochemicals applications.
参考价格
3124.36 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
664993-53-7
Tankyrase1/2 Inhibitor IV, JW55-CAS 664993-53-7-Calbiochem
TNKS1/2 Inhibitor IV, Wnt Pathway Inhibitor XVII, N-(4-((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)methylcarbamoyl)phenyl)furan-2-carboxamide
产品介绍:

产品说明

一般描述

A cell-permeable phenylcarbamoylfuran-carboxamide compound that acts as a potent, selective, and reversible inhibitor of poly(ADP-ribosyl)ation activity of tankyrase 1 and 2 (IC50 = 1.9 and 0.83 µM, respectively). Exhibits high selectivity over PARP1 (IC50 = 20 µM). Stabilizes and increases AXIN2 levels, thereby enhancing phosphorylation and degradation of β-catenin resulting in reduced canonical Wnt signaling (IC50 = 470 nM in Wnt 3a-induced HEK293 cells transfected with ST-Luc). Shown to induce cell cycle arrest and diminish the proliferation of SW480 colorectal cancer cells (~ 5 µM). Suppresses tumor growth in tamoxifen-induced polyposis in Apc knock-out murine model (100 mg/kg, i.p.). Displays adequate human liver microsomal stability (t1/2 = 10.1 min).

包装

25 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
tankyrase 1 and 2
Reversible: yes

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Waaler, J., et al. 2012. Cancer Res.72, 2822.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C25H26N2O5
分子量434.48
MDL编号MFCD03863265

产品性质

质量水平100
测定≥99% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 off-white
溶解性DMSO: 100 mg/mL
运输ambient
储存温度2-8℃
SMILES stringO=C(NCC1(CCOCC1)C2=CC=C(C=C2)OC)C3=CC=C(NC(C4=CC=CO4)=O)C=C3

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3

Sigma-Aldrich

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