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Topoisomerase II Inhibitor, BNS-22-Calbiochem

品牌
Sigma-Aldrich
货号
614853
规格纯度
The Topoisomerase II Inhibitor, BNS-22 controls the biological activity of Topoisomerase. This small molecule/inhibitor is primarily used for Cell Structure applications.
参考价格
2671.25 *本价格含增值税费
促销
服务
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  • 增值税票
数量
-+
产品名称:
Topoisomerase II Inhibitor, BNS-22-Calbiochem
BNS-22
产品介绍:

产品说明

一般描述

A potent, 2H-chromen-2-one small molecule inhibitor that is selective for TOP2 (IC50 = 2.8 µM and 0.42 µM for TOP2α and TOP2β, respectively). Unlike TOP2 poisons such as etoposide, it does not lead to DNA damage associated with DNA Double-Strand Breaks, as evidenced by the lack of γ-H2AX accumulation but instead inhibits kinetoplast DNA decatenation in vitro. This compound affects cell cycle at the M phase and disturbs mitotic spindle formation in HeLa cells at 3-10 µM. It also exhibits significant anti-proliferative activities against several human cancer cell lines.

包装

10 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Kawatani, M., et al. 2011. Chem Biol.18, 743.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C24H25NO5
分子量407.46
MDL编号MFCD22628799

产品性质

质量水平100
测定≥99% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 white
溶解性DMSO: 25 mg/mL, clear, colorless
运输ambient
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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