Monoclonal Anti-BIRC5 antibody produced in mouse

产品说明

一般描述

BIRC5 (Baculoviral inhibitor of apoptosis repeat-containing 5 ), also known as Survivin, is a transmembrane glycoprotein receptor encoded by the BIRC5 gene in humans. It consists of a unique cysteine-rich extracellular module, a single membrane-spanning domain, and a serine-rich (26%) cytoplasmic tail with at least 15 potential phosphorylation sites.

免疫原

Purified recombinant fragment of Survivin expressed in E.coli.
Mouse monoclonal antibody raised against Survivin

应用

Monoclonal Anti-BIRC5 antibody produced in mouse is suitable for direct ELISA (1:10,000), flow cytometry (1:200-1:400), immunohistochemistry (1:200-1:1,000), indirect immunofluorescence (1:200-1:1,000) and western blot (1:500-1:2,000).

生化/生理作用

BIRC5 (Baculoviral inhibitor of apoptosis repeat-containing 5) functions as a cell surface receptor for factor Xa. It is predicted to be a potential factor in protease-dependent cellular effector functions.It also behaves as a receptor for factor Xa during the cell surface assembly of proteolytic activities and leukocyte mitogenesis. A study reports that the expression of BIRC5 can be controlled by mRNA splicing. It is an inhibitor of apoptosis and is expressed in various malignancies.

外形

Ascitic fluid containing 0.03% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

产品性质

安全信息