产品说明
一般描述
The calcitonin related polypeptide α (CALCA) gene contains five exons and spans over a length of approximately 3.8 kb. It is mapped to human chromosome 11p15.2-p15.1. The gene codes for a 37-amino-acid vasoactive neuropeptide. In mammals, CALCA is expressed in the central and peripheral nervous systems.
Calcitonin is a peptide hormone synthesized by the parafollicular cells of the thyroid. It causes reduction in serum calcium, an effect opposite to that of parathyroid hormone (PTH; MIM 168450).
免疫原
CALCA (NP_001732, 52 a.a. ~ 141 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
AALVQDYVQMKASELEQEQEREGSSLDSPRSKRCGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAPGKKRDMSSDLERDHRPHVSMPQNAN
生化/生理作用
Calcitonin related polypeptide α (CALCA) acts as a potent vasodilator. This protein also has an essential role in placental angiogenesis and fetal growth. CALCA is involved in the regulation of bone calcium metabolism. Mutation in the gene might be associated with the risk of susceptibility to Parkinson′s disease, ovarian cancer and essential hypertension (EH).
外形
Solution in phosphate buffered saline, pH 7.4
法律信息
GenBank is a registered trademark of United States Department of Health and Human Services
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| MDL编号 | MFCD00162202 |
| NACRES | NA.41 |
产品性质
| 质量水平 | 100 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | 4B10, monoclonal |
| 形式 | buffered aqueous solution |
| species reactivity | human |
| technique(s) | indirect ELISA: suitable western blot: 1-5 μg/mL |
| 同位素/亚型 | IgG2aκ |
| GenBank® accession no. | NM_001741 |
| UniProt登记号 | P01258 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... CALCA(796) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
Sigma-Aldrich
m.cnreagent.com
