Monoclonal Anti-LRRC8D antibody produced in mouse

产品说明

一般描述

Leucine rich repeat containing 8 VRAC subunit D (LRRC8D) is a mammalian protein, which belongs to the family of leucine-rich repeat-containing 8 (LRRC8). It consists of four transmembrane domains at the N terminal and 17 leucine-rich repeats (LRR) at the C terminal. The gene is located on human chromosome 1p22.2.

免疫原

LRRC5 (AAH09486, 1 a.a. ~ 143 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MVSSNFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVSTSSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVEDSDLIYKLYVVQTASPFPNQ

生化/生理作用

Leucine rich repeat containing 8 VRAC subunit D (LRRC8D) is important for the translocation of neutral compounds like myo-inositol, taurine, γ-aminobutyric acid (GABA) and prolonged transport of positively charged lysine. LRRC8D deficiency is associated with reduced cellular platinum level. The protein acts as a transporter of small molecules. It is essential for the import of the antibiotic blasticidin S.

外形

Solution in phosphate buffered saline, pH 7.4

法律信息

GenBank is a registered trademark of United States Department of Health and Human Services

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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