Monoclonal Anti-STS-1 antibody produced in mouse

产品说明

一般描述

The STS1 (suppressor of T-cell receptor signaling 1) gene encodes a histidine tyrosine phosphatase, which is expressed ubiquitously. The protein contains an SH3 domain and an N-terminal ubiquitin associated domain. Its C-terminal domain is similar to the catalytic motif of phosphoglycerate mutase. The gene is also known as UBASH3B (ubiquitin associated and SH3 domain containing B) and TULA2 (T-cell ubiquitin ligand-2) and is mapped to human chromosome 11q24.1. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor.

免疫原

UBASH3B (NP_116262.2, 344 a.a. ~ 441 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
DGVLERRPYEDQGLGETTPLTIICQPMQPLRVNSQPGPQKRCLFVCRHGERMDVVFGKYWLSQCFDAKGRYIRTNLNMPHSLPQRSGGFRDYEKDAPI

生化/生理作用

The STS1 (suppressor of T-cell receptor signaling 1) protein is involved in the dephosphorylation of Syk (spleen tyrosine kinase). This gene is known to induce metastasis and invasion in breast cancer by inhibiting the action of core binding factor and thereby, controls epidermal growth factor receptor activity. The protein is considered as a potent mitosis regulator. It induces Aurora B localization and thereby promotes segregation of chromosome.

外形

Solution in phosphate buffered saline, pH 7.4

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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