Rabbit anti-PIM1 Antibody, Affinity Purified

产品说明

免疫原

The epitope recognized by PLA0088 maps to a region between residue 250 and the C-terminus (residue 313) of human PIM1 oncoprotein using the numbering given in Swiss-Prot entry P11309 (GeneID 5292).

外形

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

其他说明

PIM1 is a member of the PIM family of proto-oncogenes that functions as a distinct class of serine/threonine protein kinases involved in growth factor signaling. PIM1 was originally identified as a target of proviral activation in T-cell lymphomas induced by Moloney murine leukemia virus. PIM1 appears to play a role in many aspects of cell growth, proliferation, and apoptosis. PIM1 is required for efficient cell cycle induction of peripheral T-cells in response to IL-2 signaling. PIM1 substrates include p21 cip1/waf1, CDC25A, PTP-U2, NuMA, and PAP-1.

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Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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