Anti-AATF antibody produced in rabbit

产品说明

一般描述

AATF is a transcription factor that regulates AKT1 transcription and subsequently mediates antiapoptotic functions. Furthermore, AATF is also an antagonist of Par-4 function and inhibits aberrant production of amyloid beta peptide 1-42.
Rabbit Anti-AATF antibody recognizes human and canine AATF.

免疫原

Synthetic peptide directed towards the N terminal region of human AATF

应用

Rabbit Anti-AATF antibody can be used for western blot (0.5μg/ml) and immunohistochemistry (4-8μg/ml, using paraffin-embedded tissues) applications.

生化/生理作用

The AATF gene encodes a protein that was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.

序列

Synthetic peptide located within the following region: EEEEDEESGMEEGDDAEDSQGESEEDRAGDRNSEDDGVVMTFSSVKVSEE

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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