Anti-ALX3 antibody produced in rabbit

产品说明

一般描述

Homeobox protein aristaless-like 3 [Mus musculus] (ALX3) is found in pancreatic islets, the β-cell line MIN6, and glucogon- and somatostatin-expressing cells. ALX3 is involved in glucose homeostasis, regulation of insulin expression and prevention of apoptosis.

特异性

Anti-homeobox protein aristaless-like 3 (ALX3) polyclonal antibody detects human, rat, and mouse homeobox protein aristaless-like 3 proteins.

免疫原

Synthetic peptide directed towards the N terminal region of mouse ALX3

应用

Anti-homeobox protein aristaless-like 3 (ALX3) polyclonal antibody is used to tag homeobox protein aristaless-like 3 proteins for detection and quantitation by Western blotting and in cells and tissues by immunohistochemical (IHC) techniques. It is used as a probe to study the role of ALX3 in pancreatic islet function and insulin expression.

生化/生理作用

Mouse Alx3 is a homeobox gene that is related to the Drosophila aristaless gene and to a group of vertebrate genes including Prx1, Prx2, Cart1, and Alx4. The protein encoded contains a diverged variant of a conserved peptide sequence present near the carboxyl terminus of at least 15 different paired-class-homeodomain proteins. Alx3 is expressed in mouse embryos from 8 days of gestation onward in a characteristic pattern, predominantly in neural crest-derived mesenchyme and in lateral plate mesoderm.

序列

Synthetic peptide located within the following region: MDPERCAPFSVGPAAGPYAAAGDEAPGPQGTPDAAPHLHPAPPRGPRLSR

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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