Anti-APEX1 (AB1) antibody produced in rabbit

产品说明

一般描述

APEX1 is an endonuclease that cleaves the phosphodiester backbone at the 5′ end of the (apurinic/apyrimidinic) AP site. Mutations in APEX1 have been linked to the risk of lung cancer in Chinese populations.
Rabbit Anti-APEX1 (AB1) antibody recognizes bovine, human, mouse, rat, canine, and pig APEX1.

免疫原

Synthetic peptide directed towards the N terminal region of human APEX1

应用

Rabbit Anti-APEX1 (AB1) antibody can be used for western blot (1.25μg/ml) and IHC (4-8μg/ml) applications.

生化/生理作用

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5′ to the AP site. This gene encodes the major AP endonuclease in human cells.

序列

Synthetic peptide located within the following region: KGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWSAPSDKEGY

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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