产品说明
一般描述
APG4B is a protease that processes autophagy-related proteins such as GATE-16, Apg8L MAP1-LC3, and GABARAP.
Rabbit Anti-APG4B antibody recognizes pig, zebrafish, chicken, bovine, human, mouse, rat, and canine APG4B.
免疫原
Synthetic peptide directed towards the C terminal region of human APG4B
应用
Rabbit Anti-APG4B antibody can be used for western blot (2.0 μg/ml) and IHC (4-8 μg/ml) applications.
生化/生理作用
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. APG4B encodes a member of the autophagin protein family and is also designated as a member of the C-54 family of cysteine proteases.
序列
Synthetic peptide located within the following region: LGGALPMFELVELQPSHLACPDVLNLSLDSSDVERLERFFDSEDEDFEIL
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| MDL编号 | MFCD09753846 |
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 44 kDa |
| species reactivity | guinea pig, rabbit, mouse, human, rat, dog, horse |
| 浓度 | 0.5 mg - 1 mg/mL |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| NCBI登记号 | NP_037457 |
| UniProt登记号 | Q9Y4P1 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... APG4B(23192) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
