Anti-AWAT1, (N-terminal) antibody produced in rabbit

产品说明

一般描述

Acyl-CoA wax alcohol acyltransferase 1 (AWAT1), also known as diacylglycerol O-acyltransferase 2-like protein (DGAT2L3), is chiefly present in human skin, confined to sebaceous glands. AWAT1 is mainly present in the vertebrates. Awat1 has one transmembrane domain. The gene AWAT1 is localized on human genome on chromosome Xq13.1.

免疫原

Synthetic peptide directed towards the N terminal region of human AWAT1

生化/生理作用

The protein Acyl-CoA wax alcohol acyltransferase encoded by this gene belongs to the diacylglycerol acyltransferase family. It esterifies long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that this enzyme plays a central role in lipid metabolism in skin. Consistent with this observation, this protein is predominantly expressed in the sebaceous gland of the skin. The protein aids in preventing extreme dryness of the skin. Awat1 has higher affinity for C10 saturated fatty acids rather than longer chain unsaturated fatty acids like C16 or C18.

序列

Synthetic peptide located within the following region: LLTFGAFCNFCTEATGFSKTFPGITPHLATLSWFFKIPFVREYLMAKGVC

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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