产品说明
免疫原
Synthetic peptide directed towards the N terminal region of human C5orf39
应用
Anti-C5ORF39 antibody produced in rabbit is suitable for western blotting at a concentration of 1μg/mL.
生化/生理作用
C5ORF39 or AX2R (annexin A2 receptor) gene encodes a cell surface receptor for annexin II. It is predominantly expressed in lymphocytes, in both resting CD4+ and CD8+ T-cell. AX2R is located in cytoplasm where it binds to and stimulates pro-caspase-8 followed by caspase-3/7. Hence, AX2R induces apoptosis independent of annexin II and FADD. Annexin II binds to AXIIR and enhances the multiple myeloma cell adhesion and growth in the bone marrow microenvironment. Additionally, annexin II and its receptor AXIIR regulates adhesion, migration, homing, and growth of prostate cancer.
序列
Synthetic peptide located within the following region: EQHFLGCVKRAWDSAEVAPEPQPPPIVSSEDRGPWPLPLYPVLGEYSLDS
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 22 kDa |
| species reactivity | human |
| 浓度 | 0.5 mg - 1 mg/mL |
| technique(s) | western blot: suitable |
| NCBI登记号 | NP_001014301 |
| UniProt登记号 | Q3ZCQ2 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... C5orf39(389289) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
