Anti-CCNH antibody produced in rabbit

产品说明

一般描述

Cyclins are key regulatory proteins that control cell cycle progression by phosphorylating cyclin-dependent kinases.

免疫原

Synthetic peptide directed towards the C terminal region of human CCNH

应用

Anti- CCNH antibody produced in rabbit is suitable for western blotting at a concentration of 1 μg/ml. For immunohistochemistry of paraffin-embedded tissue sections, a concentration of 4-8 μg/ml is suitable.

生化/生理作用

Cyclin H associates with cyclin-dependent kinase7 (Cdk7) and the complex regulates RNA polymerase in several species. It regulates the transcription machinery required for larval development of zebrafish. In Arabidopsis, CCNH is essential in drought stress responses independent of cyclin dependent kinase D. The expression of CCNH is increased in humans with gastrointestinal stromal tumors.

序列

Synthetic peptide located within the following region: KQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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