Anti-CDK11A antibody produced in rabbit

产品说明

一般描述

The gene CDK11A (cyclin dependent kinase 11A) is mapped to human chromosome 1p36.33. Human genome contains two genes for CDK11, CDK11A and CDK11B. Both genes have three isoforms, the long CDK11^p110, short CDK11^p58 and CDK11^p46. CDK11^p110 is present in the nucleus, CDK11^p58 is present in the nucleus and cytoplasm, and CDK11^p46 is in the cytoplasm. CDK11^p58 is mainly expressed in the G2/M phase. CDK11^p110 is expressed during the whole cell cycle. The CDK11A protein has many NLSs (nuclear localization sequences), a 14-3-3 consensus site, an arginine/glutamic acid domain (RE domain), a poly-glutamic acid domain (poly-E domain) and a carboxy-terminal catalytic domain.

免疫原

The immunogen for anti-CDK11A antibody: synthetic peptide derected towards the C terminal of human CDK11A

生化/生理作用

CDK11 (cyclin dependent kinase 11) regulates transcription and RNA processing (mainly alternate splicing) by binding to L-type cyclins. It is also involved in cellular responses, such as hormone receptor signaling and autophagy. CDK11^p58 is needed for duplication of the centrioles, spindle rearrangement and sister chromatid cohesion at centromeres. CDK11 plays an important role in cancer cell growth and proliferation by regulating cell death.

序列

Synthetic peptide located within the following region: EYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDL

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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