Anti-COIL antibody produced in rabbit

产品说明

一般描述

Coilin is a protein encoded by the COIL gene in humans. COIL (Coilin) gene encodes a nuclear phosphoprotein localized on to chromosome 17q22-23, which is an integral component of Cajal bodies (also called coiled bodies) and impacts small nuclear ribonucleoprotein (snRNP) biogenesis.

免疫原

Synthetic peptide directed towards the C terminal region of human COIL

应用

Anti-COIL antibody produced in rabbit is suitable for western blotting at a concentration of 1μg/mL.

生化/生理作用

Coilin acts as glue to connect the CB to the nucleolus. It is considered to be the CB marker protein and is essential for proper CB formation and composition in mammalian cells. Coilin levels influences the proliferation rate and cell cycle distribution of cells exposed to etoposide. It facilitates the inhibition of RNA polymerase I during cisplatin-induced DNA damage. Coilin protein is also involved in the processing of human telomerase RNA.

序列

Synthetic peptide located within the following region: DYSLLPLLAAAPQVGEKIAFKLLELTSSYSPDVSDYKEGRILSHNPETQQ

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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