Anti-DNA Polymerase ζ, N-Terminal antibody produced in rabbit

产品说明

一般描述

The REV3L (reversionless 3-like) gene is mapped to human chromosome 6q21. It codes for a ~350 kDa protein DNA polymerase ζ which localizes to mitochondria.
Anti-DNA Polymerase ζ antibody detects endogenous levels of total DNA polymerase ζ protein.

免疫原

The antiserum was produced against synthesized peptide derived from human DNA Polymerase zeta.

Immunogen Range: 231-280

生化/生理作用

REV3L (reversionless 3-like) is predominantly involved in DNA damage response, induced by ultraviolet radiation and chemical damaging agents such as cisplatin. The encoded protein DNA Polymerase ζ catalyzes the translesion synthesis (TLS) with less stringent and lower processivity. Loss of gene function is embryonically lethal. Upregulation of REV3L results in spontaneous mutations.

特点和优势

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外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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