Anti-DNALI1 antibody produced in rabbit

产品说明

免疫原

Synthetic peptide directed towards the C terminal region of human DNALI1

应用

Anti-DNALI1 antibody produced in rabbit is suitable for western blotting at a concentration of 1μg/mL.

生化/生理作用

DNALI1 (dynein, axonemal, light intermediate chain 1) gene encodes a 258 amino acid containing protein that belongs to inner dynein arm light chain family. They are large microtubule-based motor protein complexes generating the force for the movement of eukaryotic cilia and flagella. The human hp28 (DNALI1) is localized on chromosome 1 region p35 and is predominantly expressed in spermatids. Dnali1 protein is also present in cilia of the trachea as well as in flagella of mature sperm and hence facilitates as axonemal dynein. It also has a role in the ciliary and flagellar motility. Homologous mutation in DNALI1 gene leads to situs inversus and primary ciliary dyskinesia (Kartagener Syndrome). Defect in DNALI1 gene also results in potential candidate for immotile cilia syndrome (ICS).

序列

Synthetic peptide located within the following region: ALQAEQGKSDMERKIAELETEKRDLERQVNEQKAKCEATEKRESERRQVE

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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