产品说明
一般描述
E2F transcription factor 1 (E2F1), a member of the E2F family of transcription factors, is involved in the regulation of the cell cycle. E2F1 mediates cell proliferation and p53-dependent and independent apoptosis. E2F1 binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. The Rb/E2F1 axis exerts essential functions such as maintaining epidermal homoeostasis and suppressing tumour development in tissues such as the epidermis.
特异性
Rabbit polyclonal anti-E2F1 antibody reacts with human E2F transcription factor 1.
免疫原
The immunogen for anti-E2F1 antibody: synthetic peptide derected towards the middle region of human E2F1
应用
Rabbit polyclonal anti-E2F1 antibody is used to tag E2F transcription factor 1 for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of E2F transcription factor-1 in cell proliferation, apoptosis and tissue homeostasis.
序列
Synthetic peptide located within the following region: LCPEETVGGISPGKTPSQEVTSEEENRATDSATIVSPPPSSPPSSLTTDP
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 抗体形式 | IgG fraction of antiserum |
| 质量水平 | 100 |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 47 kDa |
| species reactivity | human |
| 浓度 | 0.5 mg - 1 mg/mL |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| NCBI登记号 | NP_005216 |
| UniProt登记号 | Q01094 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... E2F1(1869) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
