Anti-E2F6 antibody produced in rabbit

产品说明

一般描述

E2F6 is a transcription factor that forms a part of the mammalian Bmi1-containing polycomb complex. This transcription factor can negatively regulate BRCA1 in human cancer cells without methylating Lysine 9 on H3 histone.
Rabbit Anti-E2F6 antibody recognizes human, mouse, rat, canine, and bovine E2F6.

免疫原

Synthetic peptide directed towards the middle region of human E2F6

应用

Rabbit Anti-E2F6 antibody can be used for western blot applications at a concentration of 0.5μg/ml. The antibody can also be used for IHC applications at 4-8μg/ml using paraffin-embedded tissues.

生化/生理作用

E2F6 encodes a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max.

序列

Synthetic peptide located within the following region: HEQIVIAVKAPAETRLDVPAPREDSITVHIRSTNGPIDVYLCEVEQGQTS

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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