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Anti-ELF3 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
AV32247
规格纯度
IgG fraction of antiserum
参考价格
3311.54 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-ELF3 antibody produced in rabbit
Anti-E74-like factor 3 (ets domain transcription factor, epithelial-specific )
产品介绍:

产品说明

一般描述

ELF3 is known to regulate light signaling to the circadian clock. It is also known to function as an epithelial-specific transcription factor.
Rabbit Anti-ELF3 antibody recognizes human, canine, mouse, rat, and bovine ELF3.

免疫原

Synthetic peptide directed towards the middle region of human ELF3

应用

Rabbit Anti-ELF3 antibody can be used for western blot applications at 2.5μg/ml.

生化/生理作用

ELF3 is a novel, highly tissue-restricted member of the ets transcription factor/oncogene family. ELF3 contains two putative DNA binding domains: an ETS domain, which is unique in that the 5′ half shows relatively weak homology to known ets factors, and an A/T hook domain, found in HMG proteins and various other nuclear factors. In contrast to any known ets factors, ELF3 is expressed exclusively in epithelial cells. ELF3 is expected to be a critical regulator of epithelial cell differentiation. ETS factor ELF3 is a transcriptional regulator of angiopoietin-1 gene regulation in the setting of inflammation. ELF3 overexpressed early during human breast tumorigenesis. ELF3 expression confers a transformed and in vitro metastatic phenotype to otherwise normal MCF-12A cells. ELF3 mediates the expression of TGF-beta RII, and the transcriptional inhibition of ets-related transcription factor could be a one of the mechanisms of colonic carcinogenesis. ELF3 is positively and negatively modulated by other interacting proteins including Ku70, Ku86, p300, and CBP.

序列

Synthetic peptide located within the following region: PGSCGAGAPSPGSSDVSTAGTGASRSSHSSDSGGSDVDLDPTDGKLFPSD

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式IgG fraction of antiserum
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量 41 kDa
species reactivityhorse, rabbit, rat, human
浓度0.5 mg - 1 mg/mL
technique(s)western blot: suitable
NCBI登记号NP_001107781
UniProt登记号P78545
运输wet ice
储存温度−20℃
Gene Informationhuman ... ELF3(1999)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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