Anti-EPLIN antibody produced in rabbit

产品说明

一般描述

EPLIN (epithelial protein lost in neoplasm or Lima-1) is known to interact with actin and couples with α-catenin. This subsequently facilitates the association of cadherin-catenin complex to F-actin stabilizing actin fibres and forming the adhesion belt. EPLIN also increases the quantity of actin stress fibers and blocks Rac-induced membrane ruffling.
Rabbit Anti-EPLIN antibody recognizes canine, bovine, pig, mouse, and human EPLIN.

免疫原

Synthetic peptide directed towards the middle region of Human LIMA1

应用

Rabbit Anti-EPLIN antibody is suitable for western blot applications at a concentration of 2.0 μg/ml.

生化/生理作用

This gene encodes a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles. It is downregulated in some cancer cell lines. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and expression of some of the variants maybe independently regulated.

序列

Synthetic peptide located within the following region: GVLAASMEAKASSQQEKEDKPAETKKLRIAWPPPTELGSSGSALEEGIKM

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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