产品说明
免疫原
Synthetic peptide directed towards the C terminal region of human FEN1
应用
Anti-FEN1 antibody produced in rabbit is suitable for western blotting at a concentration of 1.25μg/ml.
生化/生理作用
FEN-1 gene encodes a Flap structure-specific endonuclease 1 protein that belongs to XPG/RAD2 structure specific endonuclease family. It is involved in nucleotide excision repair. The protein removes the 5′ overhanging flaps in DNA repair as well as in the 5′ ends of Okazaki fragments in lagging strand DNA synthesis. FEN-1 binds Proliferating cell nuclear antigen (PCNA) and increases its endonuclease activity. It acts predominantly as an exonuclease in DNA replication in contrast to its endonuclease activity in DNA repair.
序列
Synthetic peptide located within the following region: PNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFFKVTGSL
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 42 kDa |
| species reactivity | sheep, human, mouse, dog, rat, guinea pig, horse, rabbit, bovine |
| 浓度 | 0.5 mg - 1 mg/mL |
| technique(s) | western blot: suitable |
| NCBI登记号 | NP_004102 |
| UniProt登记号 | P39748 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... FEN1(2237) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
